Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12574926 | 0.89 | PDE10A (0.52) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL2023576 | 0.78 | PDE10A (0.63) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL2023575 | 0.78 | PDE10A (0.63) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL2021420 | 0.77 | PDE10A (0.73) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL2021422 | 0.77 | PDE10A (0.73) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL7942719 | 0.73 | PDE10A (0.56) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL15538181 | 0.72 | PDE10A (1.00) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL15538177 | 0.72 | PDE10A (1.00) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL2021611 | 0.72 | PDE10A (0.63) | PDE10AALDH1A1KDM4EGAAHTT | |
| SCHEMBL2021608 | 0.72 | PDE10A (0.63) | PDE10AALDH1A1KDM4EGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010027097-A1 | TRI-SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS PDE10 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-03-11 | — | — | WO | disclosed |