Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.44 |
| ▸ | MTOR | P42345 | 13/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 12/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 12/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 16/20 | 0.43 |
| ▸ | RICTOR | Q6R327 | 9/20 | 0.43 |
| ▸ | MAPKAP1 | Q9BPZ7 | 9/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10221494 | 0.86 | MTOR (0.39) | PIK3CAMTORRPTORMLST8PIK3R1 | |
| SCHEMBL2625399 | 0.86 | MTOR (0.41) | PIK3CAMTORRPTORMLST8PIK3R1 | |
| SCHEMBL2625402 | 0.85 | MTOR (0.39) | PIK3CAMTORRPTORMLST8PIK3R1 | |
| SCHEMBL2632857 | 0.84 | MTOR (0.40) | PIK3CAMTORRPTORMLST8PIK3R1 | |
| SCHEMBL2625403 | 0.80 | PIK3R1 (0.44) | PIK3CAMTORPIK3R1 | |
| SCHEMBL2625358 | 0.75 | MTOR (0.41) | PIK3CAMTORRPTORMLST8PIK3R1 | |
| SCHEMBL10289943 | 0.75 | MTOR (0.63) | PIK3CAMTORRPTORMLST8PIK3R1 | |
| SCHEMBL2632644 | 0.74 | MTOR (0.41) | PIK3CAMTORRPTORMLST8PIK3R1 | |
| SCHEMBL7944537 | 0.74 | MTOR (0.64) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL2625391 | 0.74 | MTOR (0.46) | PIK3CAMTORRPTORMLST8PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |