Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655162 | 0.86 | PI4KB (0.65) | PI4KBKCNH2CYP3A4MAPTUSP2 | |
| SCHEMBL652821 | 0.85 | PI4KB (0.64) | PI4KBKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL654457 | 0.85 | PI4KB (0.77) | PI4KBKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL652607 | 0.85 | PI4KB (0.72) | PI4KBKCNH2CYP3A4MAPTUSP2 | |
| SCHEMBL1720407 | 0.82 | PI4KB (0.76) | PI4KBKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL654183 | 0.82 | PI4KB (0.76) | PI4KBKCNH2CYP3A4MAPTKMT2A | |
| SCHEMBL656541 | 0.82 | PI4KB (0.81) | PI4KBKCNH2CYP3A4MAPTTP53 | |
| SCHEMBL655537 | 0.82 | PI4KB (0.68) | PI4KBKCNH2CYP3A4MAPTUSP2 | |
| SCHEMBL656322 | 0.82 | PI4KB (0.86) | PI4KBKCNH2CYP3A4MAPTKMT2A | |
| SCHEMBL655045 | 0.81 | PI4KB (0.59) | PI4KBKCNH2CYP3A4MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |