Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395560 | 1.00 | HRH4 (0.61) | HRH4APEX1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL394982 | 0.86 | HRH4 (0.60) | HRH4APEX1ALDH1A1MEN1GAA | |
| SCHEMBL8653049 | 0.82 | HRH4 (0.59) | HRH4APEX1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL397240 | 0.79 | HRH4 (0.56) | HRH4KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL28585049 | 0.78 | HRH4 (0.48) | HRH4APEX1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL7881774 | 0.76 | HRH4 (0.53) | HRH4APEX1MEN1GAAMAPK1 | |
| SCHEMBL7881772 | 0.76 | HRH4 (0.53) | HRH4APEX1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL1002018 | 0.76 | TDP1 (0.52) | HRH4HSD17B10ALDH1A1MEN1CYP1A2 | |
| SCHEMBL12778290 | 0.76 | TDP1 (0.52) | HRH4APEX1ALDH1A1HPGDMEN1 | |
| SCHEMBL29812003 | 0.76 | TDP1 (0.52) | HRH4APEX1ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | disclosed |