Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 10/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7804315 | 0.91 | MAP2K1 (0.41) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035248 | 0.84 | TDP1 (0.46) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6036026 | 0.84 | MEN1 (0.48) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035421 | 0.83 | MEN1 (0.47) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035304 | 0.82 | MAP2K1 (0.59) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035749 | 0.82 | MAP2K1 (0.59) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL7787380 | 0.82 | MAP2K1 (0.45) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL6035261 | 0.80 | MAP2K1 (0.56) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL28748333 | 0.80 | MAP2K1 (0.52) | MAP2K1MAP2K2MEN1KMT2ATDP1 | |
| SCHEMBL7941495 | 0.79 | MAP2K1 (0.47) | MAP2K1MAP2K2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140291-A1 | COMBINATION CHEMOTHERAPY COMPRISING A MITOTIC INHIBITOR AND A MEK INHIBITOR | WARNER-LAMBERT COMPANY LLC (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037141-A9 | COMBINATION CHEMOTHERAPY | WARNER LAMBERT CO (US) | 2000-12-07 | — | — | WO | disclosed |
| WO-2000037141-A1 | COMBINATION CHEMOTHERAPY | WARNER-LAMBERT COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |