Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655575 | 0.95 | PI4KB (0.56) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL654086 | 0.93 | PI4KB (0.51) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL655387 | 0.93 | PI4KB (0.53) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL656446 | 0.92 | PI4KB (0.53) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL653116 | 0.92 | PI4KB (0.50) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL655043 | 0.91 | PI4KB (0.53) | PI4KBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL653219 | 0.91 | PI4KB (0.53) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL656564 | 0.91 | PI4KB (0.64) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL656254 | 0.90 | PI4KB (0.51) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL1719921 | 0.90 | PI4KB (0.62) | PI4KBENPP2ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-B1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | UNIV LEUVEN KATH (BE) | 2016-08-31 | — | — | EP | claimed |
| EP-2405973-B1 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | UNIV LEUVEN KATH (BE) | 2015-04-22 | — | — | EP | claimed |
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | claimed |