Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 11/20 | 0.50 |
| ▸ | PRKCI | P41743 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944189 | 0.92 | PRKCI (0.47) | GRM4PRKCIBACE1CYP1A2CYP3A4 | |
| SCHEMBL7941379 | 0.87 | BACE1 (0.53) | GRM4PRKCIBACE1 | |
| SCHEMBL7939915 | 0.87 | BACE1 (0.48) | GRM4PRKCIBACE1 | |
| SCHEMBL7933421 | 0.86 | BACE1 (0.62) | GRM4BACE1CYP1A2CYP3A4 | |
| SCHEMBL7945287 | 0.85 | GRM4 (0.48) | GRM4BACE1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL7940998 | 0.84 | GAA (0.50) | GRM4PRKCIBACE1 | |
| SCHEMBL7940397 | 0.82 | PRKCI (0.47) | GRM4PRKCIBACE1 | |
| SCHEMBL7941783 | 0.82 | BACE1 (0.45) | PRKCIBACE1CYP3A4 | |
| SCHEMBL7941882 | 0.82 | BACE1 (0.47) | PRKCIBACE1 | |
| SCHEMBL7942897 | 0.82 | JAK2 (0.51) | GRM4PRKCIBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237576-A1 | 2-AMINOPYRIMIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVES BOTH HAVING BACE1-INHIBITING ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2011-09-29 | — | — | US | disclosed |
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237576-A1 | 2-AMINOPYRIMIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVES BOTH HAVING BACE1-INHIBITING ACTIVITY | BACE1, APP, BACE2 | GRM4 2438/4885PRKCI 2747/4885BACE1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.