Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602306 | 0.81 | MAPT (0.45) | MAPTPDE4DCYP2C19CYP1A2CYP3A4 | |
| SCHEMBL6601028 | 0.77 | HDAC8 (0.45) | MAPTPDE4DCYP3A4SMN1; SMN2HDAC8 | |
| SCHEMBL7656826 | 0.76 | MAPT (0.43) | MAPTPDE4DCYP2C19CYP1A2CYP3A4 | |
| SCHEMBL6601821 | 0.75 | MAPT (0.42) | MAPTPDE4DALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6602418 | 0.75 | ESR1 (0.47) | MAPTPDE4DSMN1; SMN2POLBHDAC8 | |
| SCHEMBL6601241 | 0.74 | MAPT (0.44) | MAPTPDE4DCYP2C19CYP1A2CYP3A4 | |
| SCHEMBL6605922 | 0.74 | PDE4D (0.43) | MAPTPDE4DCYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7662210 | 0.74 | MAPT (0.46) | MAPTPDE4DCYP2C19CYP1A2CYP3A4 | |
| SCHEMBL6602605 | 0.74 | MAPT (0.48) | MAPTPDE4DRAB9AGAA | |
| SCHEMBL5874082 | 0.74 | MAPT (0.47) | MAPTPDE4DCYP2C19CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248754-B1 | PSYCHOLOGICAL DISORDERS | SMITHKLINE BEECHAM, P.L.C. (GB) | 2001-06-19 | — | — | US | disclosed |