Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.54 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440795 | 0.92 | MTOR (0.57) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL440794 | 0.92 | MTOR (0.57) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL444090 | 0.91 | MTOR (0.62) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL412544 | 0.91 | MTOR (0.62) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL1831328 | 0.88 | MTOR (0.76) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL411859 | 0.88 | MTOR (0.60) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL443771 | 0.88 | MTOR (0.76) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL411849 | 0.88 | MTOR (0.76) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL442164 | 0.88 | MTOR (0.60) | MTORPIK3CAKCNH2CYP3A4RPTOR | |
| SCHEMBL15196055 | 0.88 | MTOR (0.54) | MTORPIK3CAKCNH2CYP3A4RPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |