Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945788 | 0.86 | ESR1 (0.53) | ESR1ESR2 | |
| SCHEMBL7936791 | 0.83 | PRNP (0.55) | ESR1ESR2 | |
| SCHEMBL8637183 | 0.79 | ESR1 (0.60) | ESR1ESR2 | |
| SCHEMBL7945789 | 0.79 | ESR1 (0.52) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL8626952 | 0.76 | ESR1 (0.80) | ESR1ESR2 | |
| SCHEMBL29670038 | 0.75 | RPA1 (0.36) | ESR1ESR2 | |
| SCHEMBL28770285 | 0.75 | RPA1 (0.36) | ESR1ESR2 | |
| SCHEMBL1665657 | 0.75 | ESR1 (0.86) | ESR1ESR2 | |
| SCHEMBL8635521 | 0.75 | ESR1 (0.52) | ESR1ESR2HDAC3HDAC1HDAC2 | |
| SCHEMBL30898315 | 0.75 | ESR1 (0.52) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | claimed |
| US-6087378-A | THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2000-07-11 | — | — | US | claimed |
| US-6258826-B1 | HALOGEN SUBSTITUTED BENZOTHIOPHENE COMPOUNDS WITH CARRIERS | ELI LILLY AND COMPANY | 2001-07-10 | — | — | US | disclosed |
| US-6087378-A | THE ACTIVE BENZO(B)THIOPHENE COMPOUNDS FOR TREATING OSTEOPOROSIS AND CARDIOVASCULAR DISORDERS, ESPECIALLY HYPERLIPIDEMIA | ELI LILLY AND COMPANY (US) | 2000-07-11 | — | — | US | disclosed |