Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654675 | 0.94 | PI4KB (0.59) | PI4KBKMT2AMEN1GPR183ESR1 | |
| SCHEMBL654623 | 0.94 | PI4KB (0.59) | PI4KBKMT2AMEN1GPR183ESR1 | |
| SCHEMBL654810 | 0.86 | PI4KB (0.57) | PI4KBKMT2AMEN1GPR183ESR1 | |
| SCHEMBL654267 | 0.82 | PI4KB (0.61) | PI4KBKMT2AMEN1GPR183POLB | |
| SCHEMBL655515 | 0.80 | PI4KB (0.61) | PI4KBKMT2AMEN1GPR183POLB | |
| SCHEMBL4418674 | 0.79 | PI4KB (0.59) | PI4KBKMT2AMEN1GPR183POLB | |
| SCHEMBL652287 | 0.77 | PI4KB (0.66) | PI4KBKMT2AMEN1GPR183POLB | |
| SCHEMBL654583 | 0.77 | PI4KB (0.66) | PI4KBKMT2AMEN1GPR183ESR1 | |
| SCHEMBL654098 | 0.76 | PI4KB (0.62) | PI4KBKMT2AMEN1GPR183POLB | |
| SCHEMBL654714 | 0.76 | MEN1 (0.53) | PI4KBKMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2405973-A2 | THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2012-01-18 | — | — | EP | disclosed |
| WO-2011147753-A1 | ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) | 2011-12-01 | — | — | WO | disclosed |