Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 5/20 | 0.38 |
| ▸ | TOP2A | P11388 | 3/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960397 | 1.00 | KDM4E (0.43) | KDM4EPDE4AKCNH2GSK3BTOP2A | |
| SCHEMBL7960402 | 0.90 | PDE4A (0.43) | PDE4AKCNH2HTR6PKM | |
| SCHEMBL7966136 | 0.90 | ELANE (0.46) | PDE4AKCNH2HTR6HTR3A | |
| SCHEMBL7955415 | 0.90 | PDE4A (0.43) | PDE4AKCNH2HTR6PKM | |
| SCHEMBL7966137 | 0.90 | ELANE (0.46) | PDE4AKCNH2HTR6HTR3A | |
| SCHEMBL7963505 | 0.90 | PDE4A (0.46) | PDE4AKCNH2 | |
| SCHEMBL7960314 | 0.90 | PDE4A (0.46) | PDE4AKCNH2 | |
| SCHEMBL7966424 | 0.88 | PDE4A (0.43) | PDE4AKCNH2 | |
| SCHEMBL7951809 | 0.88 | PDE4A (0.43) | PDE4AKCNH2 | |
| SCHEMBL7951811 | 0.88 | PDE4A (0.43) | PDE4AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |