SCHEMBL7946435

SCHEMBL7946435

NC(=O)c1c(Cl)c(-c2cccnc2Cl)n2c1C=C(Cl)CC2

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.34
DHODH Q02127 2/20 0.32
ALDH1A1 P00352 1/20 0.32
SMN1; SMN2 Q16637 3/20 0.31
LMNA P02545 1/20 0.31
KDM4E B2RXH2 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
MKNK1 Q9BUB5 1/20 0.30
MKNK2 Q9HBH9 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7955537 0.89 MKNK1 (0.41) MKNK1MKNK2
SCHEMBL7963043 0.89 PLAU (0.33) DHODHMKNK1MKNK2
SCHEMBL7967099 0.89 DHODH (0.34) DHODHALDH1A1SMN1; SMN2LMNAKDM4E
SCHEMBL7965202 0.86 HPGD (0.32) HPGDDHODH
SCHEMBL7961927 0.86 IDO1 (0.35) HPGDDHODHALDH1A1SMN1; SMN2LMNA
SCHEMBL7965560 0.82 HPGD (0.32) HPGDDHODHALDH1A1SMN1; SMN2LMNA
SCHEMBL7953077 0.80 MKNK1 (0.40) MKNK1MKNK2
SCHEMBL7955530 0.78 HPGD (0.39) HPGDDHODHALDH1A1SMN1; SMN2LMNA
SCHEMBL7961290 0.78 DHODH (0.33) DHODH
SCHEMBL7968043 0.77 KDM4E (0.32) ALDH1A1SMN1; SMN2KDM4ECYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207675-B1 FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA RHONE-POULENC RORER S.A. (FR) 2001-03-27 US disclosed
US-6194426-B1 CONTROLLING TUMOR NECROSIS FACTOR RHONA-POULENC RORER S.A. (FR) 2001-02-27 US disclosed
EP-0946555-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Aventis Pharma S.A. (FR) 1999-10-06 EP disclosed
WO-1998025925-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1998-06-18 WO disclosed
EP-0833635-A1 NOVEL USE FOR PYRROLE DERIVATIVES Aventis Pharma S.A. (FR) 1998-04-08 EP disclosed
WO-1997000073-A1 NOVEL USE FOR PYRROLE DERIVATIVES RHONE-POULENC RORER S.A. (FR) 1997-01-03 WO disclosed