Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 3/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951798 | 1.00 | KDM4E (0.47) | KDM4ETOP2ATOP2BKCNH2PDE4A | |
| SCHEMBL7960307 | 0.91 | KDM4E (0.55) | KDM4ETOP2ATOP2BKCNH2PDE4A | |
| SCHEMBL7963083 | 0.89 | KDM4E (0.46) | KDM4ETOP2ATOP2BKCNH2PDE4A | |
| SCHEMBL7963082 | 0.89 | KDM4E (0.46) | KDM4ETOP2ATOP2BKCNH2PDE4A | |
| SCHEMBL7966256 | 0.87 | ELANE (0.53) | PKMHTR3AELANE | |
| SCHEMBL7966257 | 0.87 | ELANE (0.53) | PKMHTR3AELANE | |
| SCHEMBL7963122 | 0.86 | KDM4E (0.51) | KDM4ETOP2ATOP2BKCNH2PDE4A | |
| SCHEMBL7963124 | 0.86 | KDM4E (0.51) | KDM4ETOP2ATOP2BKCNH2PDE4A | |
| SCHEMBL7946345 | 0.86 | KDM4E (0.63) | KDM4ETOP2ATOP2BKCNH2PDE4A | |
| SCHEMBL7951788 | 0.86 | KDM4E (0.60) | KDM4ETOP2ATOP2BKCNH2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |