Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.67 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7935576 | 0.94 | BACE1 (0.67) | BACE1BACE2APP | |
| SCHEMBL7943263 | 0.94 | BACE1 (0.67) | BACE1BACE2APP | |
| SCHEMBL7939450 | 0.94 | BACE1 (0.67) | BACE1BACE2APP | |
| SCHEMBL7939452 | 0.94 | BACE1 (0.67) | BACE1BACE2APP | |
| SCHEMBL7946581 | 0.93 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL7945195 | 0.92 | BACE1 (0.65) | BACE1BACE2APP | |
| SCHEMBL7941607 | 0.91 | BACE1 (0.77) | BACE1BACE2 | |
| SCHEMBL7942077 | 0.90 | BACE1 (0.77) | BACE1BACE2 | |
| SCHEMBL7941613 | 0.89 | BACE1 (0.64) | BACE1BACE2 | |
| SCHEMBL7944165 | 0.89 | BACE1 (0.75) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010047372-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-04-29 | — | — | WO | disclosed |