Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.59 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.52 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945254 | 1.00 | MTOR (0.59) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL1832991 | 0.90 | MTOR (0.73) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL1832990 | 0.90 | MTOR (0.73) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL2632815 | 0.90 | MTOR (0.73) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL1833628 | 0.90 | MTOR (0.73) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL1832993 | 0.90 | MTOR (0.73) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL7942557 | 0.89 | MTOR (0.54) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL7942555 | 0.89 | MTOR (0.54) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL7942731 | 0.83 | MTOR (0.55) | MTORRPTORMLST8PIK3CAKCNH2 | |
| SCHEMBL7947515 | 0.83 | MTOR (0.55) | MTORRPTORMLST8PIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |