Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 3/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1837535 | 0.76 | NR1H2 (0.36) | NR1H2C5AR1BUB1CCNA2CDK2 | |
| SCHEMBL16627099 | 0.73 | CDK2 (0.43) | NR1H2C5AR1CCNA2CDK2CCNA1 | |
| SCHEMBL17536005 | 0.73 | BUB1 (0.39) | NR1H2USP2SMN1; SMN2C5AR1BUB1 | |
| SCHEMBL19195046 | 0.72 | NR1H2 (0.38) | NR1H2C5AR1BUB1CCNA2CDK2 | |
| SCHEMBL26407436 | 0.72 | NR1H2 (0.35) | NR1H2C5AR1CCNA2CDK2CCNA1 | |
| SCHEMBL1368936 | 0.72 | CDK2 (0.42) | NR1H2C5AR1CCNA2CDK2CCNA1 | |
| SCHEMBL17536013 | 0.70 | CHRM2 (0.39) | NR1H2USP2SMN1; SMN2BUB1 | |
| SCHEMBL22095959 | 0.68 | C5AR1 (0.39) | NR1H2C5AR1CCNA2CDK2CCNA1 | |
| SCHEMBL23537542 | 0.66 | NR1H2 (0.35) | NR1H2USP2SMN1; SMN2C5AR1BUB1 | |
| SCHEMBL23537540 | 0.66 | NR1H2 (0.35) | NR1H2USP2SMN1; SMN2C5AR1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2010014939-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-02-04 | — | — | WO | disclosed |