Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 2/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.33 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.33 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.33 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.33 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856956 | 1.00 | HTRA1 (0.36) | HTRA1SCN3ASCN4ADRD2ELANE | |
| SCHEMBL1930657 | 1.00 | HTRA1 (0.36) | HTRA1SCN3ASCN4ADRD2ELANE | |
| SCHEMBL19856958 | 0.94 | STAT6 (0.35) | HTRA1SCN3ASCN4ADRD2STAT6 | |
| SCHEMBL19856962 | 0.94 | STAT6 (0.35) | HTRA1SCN3ASCN4ADRD2STAT6 | |
| SCHEMBL7945339 | 0.92 | STAT6 (0.35) | HTRA1SCN3ASCN4ADRD2ELANE | |
| SCHEMBL19856880 | 0.92 | STAT6 (0.35) | HTRA1SCN3ASCN4ADRD2ELANE | |
| SCHEMBL1931566 | 0.92 | STAT6 (0.35) | HTRA1SCN3ASCN4ADRD2ELANE | |
| SCHEMBL7933956 | 0.92 | SCN3A (0.37) | HTRA1SCN3ASCN4ADRD2STAT6 | |
| SCHEMBL7942793 | 0.92 | SCN3A (0.37) | HTRA1SCN3ASCN4ADRD2STAT6 | |
| SCHEMBL1930659 | 0.90 | HTRA1 (0.35) | HTRA1SCN3ASCN4ADRD2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010011914-A1 | TRPV4 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |