Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | CHKA | P35790 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23610369 | 0.88 | KDM4E (0.71) | KDM4EUSP2CHEK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17737082 | 0.88 | KDM4E (0.71) | KDM4EUSP2CHEK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4579770 | 0.85 | POLB (0.61) | KDM4ESMN1; SMN2CYP3A4ALDH1A1ITGB3 | |
| SCHEMBL5632521 | 0.85 | POLB (0.54) | KDM4ESMN1; SMN2ALDH1A1ITGB3ITGA2B | |
| SCHEMBL7961639 | 0.84 | SMN1; SMN2 (0.70) | KDM4EUSP2SMN1; SMN2AKR1C3CYP3A4 | |
| SCHEMBL4033968 | 0.84 | CHEK1 (0.56) | CHEK1SMN1; SMN2AKR1C3CHKACYP3A4 | |
| SCHEMBL7956272 | 0.84 | NPC1 (0.69) | SMN1; SMN2AKR1C3CHKACYP3A4ALDH1A1 | |
| SCHEMBL7404283 | 0.83 | POLB (0.55) | KDM4ESMN1; SMN2ALDH1A1HRH3MAPT | |
| SCHEMBL7400408 | 0.82 | KMT2A (0.58) | KDM4ECHEK1SMN1; SMN2CYP3A4ALDH1A1 | |
| SCHEMBL20193318 | 0.82 | KDM4E (0.65) | KDM4EUSP2CHEK1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |