Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.43 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20614282 | 1.00 | RAD52 (0.58) | RAD52SMN1; SMN2LMNAHRH3CYP2C9 | |
| SCHEMBL6973435 | 0.98 | RAD52 (0.55) | RAD52SMN1; SMN2LMNAHRH3CYP2C9 | |
| SCHEMBL6493217 | 0.94 | RAD52 (0.59) | RAD52SMN1; SMN2LMNAHRH3CYP2C9 | |
| SCHEMBL6503351 | 0.94 | RAD52 (0.59) | RAD52SMN1; SMN2LMNAHRH3CYP2C9 | |
| SCHEMBL3446318 | 0.88 | RAD52 (0.72) | RAD52SMN1; SMN2HRH3CYP2C9CYP1A2 | |
| SCHEMBL13045564 | 0.85 | GAA (0.62) | RAD52SMN1; SMN2LMNAEPHX1GAA | |
| SCHEMBL7511788 | 0.85 | RAD52 (0.51) | RAD52SMN1; SMN2LMNAHRH3CYP2C9 | |
| SCHEMBL11507 | 0.85 | HRH3 (0.48) | RAD52SMN1; SMN2LMNAHRH3CYP2C9 | |
| SCHEMBL13771289 | 0.85 | GAA (0.62) | RAD52SMN1; SMN2LMNAEPHX1GAA | |
| SCHEMBL17484488 | 0.85 | RAD52 (0.60) | RAD52SMN1; SMN2LMNAHRH3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |