Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.70 |
| ▸ | EDNRB | P24530 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | NSD2 | O96028 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949496 | 0.87 | EDNRA (0.76) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| Bms-182874 SCHEMBL802730 | 0.82 | EDNRA (1.00) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| SCHEMBL7951138 | 0.82 | EDNRA (0.74) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| Bms-182874 SCHEMBL117150 | 0.82 | EDNRA (0.98) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| SCHEMBL7857311 | 0.81 | EDNRA (1.00) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| SCHEMBL7939545 | 0.80 | EDNRA (0.74) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| SCHEMBL7948240 | 0.77 | EDNRA (0.72) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| SCHEMBL7857611 | 0.77 | SMN1; SMN2 (0.53) | EDNRAEDNRBKDM4EMEN1HPGD | |
| SCHEMBL8784615 | 0.77 | EDNRA (0.76) | EDNRAEDNRBKDM4ETSHRHSD17B10 | |
| SCHEMBL7939688 | 0.74 | EDNRA (0.67) | EDNRAEDNRBKDM4ETSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | claimed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| EP-0558258-B1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | SQUIBB & SONS INC (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5378715-A | Sulfonamide endothelin antagonists | BRISTOL-MYERS SQUIBB CO. (US) | 1995-01-03 | — | — | US | disclosed |
| EP-0558258-A1 | N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-09-01 | — | — | EP | disclosed |