Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 13/20 | 0.50 |
| ▸ | PTGIR | P43119 | 13/20 | 0.50 |
| ▸ | CASP1 | P29466 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958928 | 0.88 | TBXA2R (0.52) | TBXA2RPTGIRCASP1MMP8MMP12 | |
| SCHEMBL7956738 | 0.82 | TBXA2R (0.51) | TBXA2RPTGIRCASP1KDM4EALDH1A1 | |
| SCHEMBL7963013 | 0.81 | TBXA2R (0.52) | TBXA2RPTGIRMMP8MMP12MMP13 | |
| SCHEMBL7958541 | 0.80 | PTGIR (0.55) | TBXA2RPTGIRMMP8MMP12MMP13 | |
| SCHEMBL7956039 | 0.79 | TBXA2R (0.45) | TBXA2RPTGIRKDM4EALDH1A1HPGD | |
| SCHEMBL7958687 | 0.79 | TBXA2R (0.50) | TBXA2RPTGIRKDM4EALDH1A1HPGD | |
| SCHEMBL7948722 | 0.75 | TBXA2R (0.56) | TBXA2RPTGIRKDM4EALDH1A1HPGD | |
| SCHEMBL7956328 | 0.74 | PTGIR (0.53) | TBXA2RPTGIRCASP1MMP8MMP12 | |
| SCHEMBL7966601 | 0.74 | TBXA2R (0.52) | TBXA2RPTGIRKDM4EALDH1A1HPGD | |
| SCHEMBL7948729 | 0.74 | PTGIR (0.52) | TBXA2RPTGIRCASP1MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323235-B1 | CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS AND ENZYME INHIBITORS | OHTAKE ATSUSHI (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6043264-A | A THROMBOXANE A2 RECEPTOR ANTAGONIST FOR TREATING HYPERTENSION, THROMBOSIS, ISCHEMIC HEART DISEASES, CIRCULATORY DISEASES, ARTERIOSCLEROSIS, PLATELET FUNCTION DISORDER, HYPERLIPIDEMIA, NEPHRITIS OR ASTHMA | TORAY INDUSTRIES, INC. (JP) | 2000-03-28 | — | — | US | disclosed |
| EP-0751126-A1 | BENZENE-FUSED HETEROCYCLIC DERIVATIVE AND USE OF THE SAME | TORAY INDUSTRIES, INC. (JP) | 1997-01-02 | — | — | EP | disclosed |