Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180898 | 1.00 | TDP1 (0.56) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL7948888 | 1.00 | TDP1 (0.56) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL11454521 | 0.81 | TDP1 (0.60) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL29444183 | 0.79 | TDP1 (0.58) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL672680 | 0.79 | TDP1 (0.58) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL1689789 | 0.79 | TDP1 (0.58) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL672679 | 0.79 | TDP1 (0.58) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL2181990 | 0.79 | TDP1 (0.58) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL1689790 | 0.79 | TDP1 (0.58) | TDP1TTRMAPTALDH1A1KDM4E | |
| SCHEMBL29194424 | 0.77 | TDP1 (0.56) | TDP1TTRMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |