SCHEMBL7949840

SCHEMBL7949840

Clc1cc(I)cc2ncccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.49
KDM4E B2RXH2 6/20 0.49
LMNA P02545 6/20 0.49
ALDH1A1 P00352 4/20 0.49
HSP90AA1 P07900 4/20 0.49
MEN1 O00255 4/20 0.49
HTT P42858 4/20 0.49
KMT2A Q03164 4/20 0.49
SMN1; SMN2 Q16637 4/20 0.49
TDP1 Q9NUW8 4/20 0.49
MMP14 P50281 3/20 0.49
CYP3A4 P08684 3/20 0.49
TP53 P04637 3/20 0.49
ALOX15 P16050 3/20 0.49
SLC6A2 P23975 3/20 0.49
ALOX12 P18054 2/20 0.49
OPRK1 P41145 2/20 0.49
NR4A2 P43354 2/20 0.49
METAP2 P50579 2/20 0.49
METAP1 P53582 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30393983 1.00 MAPT (0.49) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL7712335 0.80 NR4A2 (0.67) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL18848333 0.80 KDM4E (0.48) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL29702168 0.80 NR4A2 (0.67) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL30908289 0.77 NR4A2 (0.49) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL4433754 0.77 NR4A2 (0.58) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL17838999 0.77 NR4A2 (0.49) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL3454205 0.77 NR4A2 (0.49) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL18572649 0.77 KDM4E (0.53) MAPTKDM4ELMNAALDH1A1HSP90AA1
SCHEMBL17839007 0.77 NR4A2 (0.49) MAPTKDM4ELMNAALDH1A1HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117241781-A Loading of alginate microspheres 德克萨斯大学系统董事会 2023-12-15 CN disclosed
EP-4029518-A1 COMBINATIONAL USES OF NITROXOLINE AND ITS ANALOGUES WITH CHEMOTHERAPIES AND IMMUNOTHERAPIES IN THE TREATMENT OF CANCERS Jiangsu Yahong Meditech Co., Ltd. (CN) 2022-07-20 EP disclosed
EP-4029517-A1 COMBINATIONAL USES OF NITROXOLINE AND ITS ANALOGUES WITH CHEMOTHERAPIES AND IMMUNOTHERAPIES IN THE TREATMENT OF CANCERS Jiangsu Yahong Meditech Co., Ltd. (CN) 2022-07-20 EP disclosed
US-20220218691-A1 COMBINATIONAL USES OF NITROXOLINE AND ITS ANALOGUES WITH CHEMOTHERAPIES AND IMMUNOTHERAPIES IN THE TREATMENT OF CANCERS ASIERIS PHARMACEUTICAL TECHNOLOGIES CO., LTD. (VG) 2022-07-14 US disclosed
US-20220218692-A1 COMBINATIONAL USES OF NITROXOLINE AND ITS ANALOGUES WITH CHEMOTHERAPIES AND IMMUNOTHERAPIES IN THE TREATMENT OF CANCERS ASIERIS PHARMACEUTICAL TECHNOLOGIES CO., LTD. (VG) 2022-07-14 US disclosed
US-11324739-B2 Combinational uses of nitroxoline and its analogues with chemotherapies and immunotherapies in the treatment of cancers JIANGSU YAHONG MEDITECH CO., LTD. (CN) 2022-05-10 US disclosed
US-20190275025-A1 COMBINATIONAL USES OF NITROXOLINE AND ITS ANALOGUES WITH CHEMOTHERAPIES AND IMMUNOTHERAPIES IN THE TREATMENT OF CANCERS PAN-SCIENTIFIC HOLDINGS CO., LTD. (VG) 2019-09-12 US disclosed
EP-3436071-A1 COMBINATIONAL USES OF NITROXOLINE AND ITS ANALOGUES WITH CHEMOTHERAPEIS AND IMMUNOTHERAPIES IN THE TREATMENT OF CANCERS Asieris Pharmaceutical Technologies Co., Ltd. (VG) 2019-02-06 EP disclosed
WO-2017173278-A1 COMBINATIONAL USES OF NITROXOLINE AND ITS ANALOGUES WITH CHEMOTHERAPEIS AND IMMUNOTHERAPIES IN THE TREATMENT OF CANCERS ASIERIS PHARMACEUTICAL TECHNOLOGIES CO., LTD. (VG) 2017-10-05 WO disclosed
US-9758484-B2 Base addition salts of nitroxoline and uses thereof ASIERIS PHARMACEUTICAL TECHNOLOGIES CO., LTD. (CN) 2017-09-12 US disclosed
US-20160031819-A1 BASE ADDITION SALTS OF NITROXOLINE AND USES THEREOF PAN-SCIENTIFIC HOLDINGS CO., LTD. (VG) 2016-02-04 US disclosed
EP-2970128-A1 BASE ADDITION SALTS OF NITROXOLINE AND USES THEREOF Asieris Pharmaceutical Technologies Co., Ltd. (CN) 2016-01-20 EP disclosed
WO-2014145723-A1 BASE ADDITION SALTS OF NITROXOLINE AND USES THEREOF PAN KE (US) 2014-09-18 WO disclosed
CN-1681791-B 8-hydroxy quinoline derivatives PRANA BIOTECHNOLOGY LTD 2013-03-27 CN disclosed
WO-2001082911-A2 TREATMENT OF PATHOLOGICAL CONDITIONS INFLUENCED BY THE ACTION OF MATRIX METALLOPROTEINASES (MMPs) USING CLIOQUINOL GEROLYMATOS P N SA (GR) 2001-11-08 WO disclosed
US-6001852-A AND AN AMOUNT OF VITAMIN B.SUB.12 EFFECTIVE TO INHIBIT A DETRIMENTAL SIDE EFFECT P.N. GEROLYMATOS S.A. (GR) 1999-12-14 US disclosed
US-5994323-A SYNERGISTIC MIXTURE; ALZHEIMER'S, PARKINSON'S DISEASE P.N. GEROLYMATOS S.A. (GR) 1999-11-30 US disclosed
US-5980914-A ADMINISTERING AN AMOUNT OF CLIOQUINOL WITH VITAMIN B12 EFFECTIVE TO TREAT OR DELAY THE ONSET OF PARKINSON'S DISEASE P.N. GEROLYMATOS S.A. (GR) 1999-11-09 US disclosed
WO-1999034807-A1 PHARMACEUTICAL COMPOSITION COMPRISING CLIOQUINOL AND VITAMIN B¿12? P.N. GEROLYMATOS S.A. (GR) 1999-07-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160031819-A1 BASE ADDITION SALTS OF NITROXOLINE AND USES THEREOF SLC28A1, SLC28A2, NNT MAPT 1375/4885KDM4E 4309/4885LMNA 2567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.