Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | PDE5A | O76074 | 18/20 | 0.69 |
| ▸ | PDE6C | P51160 | 3/20 | 0.69 |
| ▸ | PDE1A | P54750 | 2/20 | 0.69 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.69 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.64 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.62 |
| ▸ | PDE6D | O43924 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18715171 | 0.90 | PDE5A (0.75) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL18715297 | 0.88 | PDE5A (0.72) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL7959546 | 0.87 | PDE5A (0.73) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL17404875 | 0.87 | PDE5A (0.81) | PDE5APDE6CHDAC6HDAC1HDAC2 | |
| SCHEMBL7950435 | 0.86 | KMT2A (0.77) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL17390172 | 0.86 | PDE5A (0.76) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL7950384 | 0.85 | PDE5A (0.71) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL17390111 | 0.85 | PDE5A (0.71) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL8803457 | 0.84 | PDE5A (0.72) | KMT2APDE5APDE6CPDE1APDE1B | |
| SCHEMBL16003765 | 0.84 | PDE5A (0.89) | PDE5APDE6CHDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0526004-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1997-10-08 | — | — | EP | disclosed |
| US-5426107-A | Treatment of cardiovascular disorders, asthma, allergies | PFIZER INC. (US) | 1995-06-20 | — | — | US | disclosed |
| US-5272147-A | Pyrazolopyrimidinone antianginal agents | PFIZER INC. (US) | 1993-12-21 | — | — | US | disclosed |
| EP-0526004-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1993-02-03 | — | — | EP | disclosed |