Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969845 | 0.87 | ATM (0.49) | ATML3MBTL1KDM4EHTTEPHX2 | |
| SCHEMBL7959012 | 0.81 | ATM (0.71) | ATML3MBTL1KDM4EHTTHDAC3 | |
| SCHEMBL7962860 | 0.79 | ATM (0.43) | ATML3MBTL1KDM4EHTTEPHX2 | |
| SCHEMBL7957289 | 0.79 | KDM4E (0.68) | ATML3MBTL1KDM4EHTTHDAC3 | |
| SCHEMBL7957389 | 0.74 | ATM (0.47) | ATML3MBTL1KDM4EHTTHDAC3 | |
| SCHEMBL7959041 | 0.72 | KDM4E (0.52) | ATML3MBTL1KDM4EHTTHDAC3 | |
| SCHEMBL7957374 | 0.72 | KDM4E (0.56) | ATML3MBTL1KDM4EHTTHDAC3 | |
| SCHEMBL7959111 | 0.72 | KDM4E (0.46) | ATML3MBTL1KDM4EHTTEPHX2 | |
| SCHEMBL1830586 | 0.72 | ATM (0.48) | ATML3MBTL1KDM4EHTTEPHX2 | |
| SCHEMBL7958225 | 0.72 | KDM4E (0.54) | ATML3MBTL1KDM4EHTTHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |