Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | NEK4 | P51957 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982560 | 0.81 | F10 (0.52) | F10MAPK1ROCK1ROCK2PPARG | |
| SCHEMBL6982556 | 0.81 | F10 (0.52) | F10MAPK1ROCK1ROCK2PPARG | |
| SCHEMBL6981248 | 0.80 | F10 (0.54) | F10MAPK1NPC1RAB9AROCK1 | |
| SCHEMBL7133910 | 0.78 | F10 (0.50) | F10MAPK1ALDH1A1ROCK1ROCK2 | |
| SCHEMBL6978044 | 0.77 | F10 (0.49) | F10MAPK1ROCK1ROCK2RPS6KA5 | |
| SCHEMBL6978051 | 0.77 | F10 (0.49) | F10MAPK1ROCK1ROCK2RPS6KA5 | |
| SCHEMBL6983225 | 0.75 | F10 (0.49) | F10MAPK1ROCK1ROCK2RPS6KA5 | |
| SCHEMBL6983223 | 0.74 | F10 (0.49) | F10MAPK1ROCK1ROCK2 | |
| SCHEMBL6978654 | 0.73 | F10 (0.48) | F10MAPK1ROCK1ROCK2AKT1 | |
| SCHEMBL6978650 | 0.73 | F10 (0.47) | F10MAPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262069-B1 | 1-amino-7-isoquinoline derivatives as serine protease inhibitors | PROTHERICS MOLECULAR DESIGN LIMITED (GB) | 2001-07-17 | — | — | US | disclosed |