Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14780864 | 1.00 | HDAC6 (0.51) | HDAC6HDAC8HDAC1GFERMAPT | |
| SCHEMBL1366277 | 0.87 | HDAC6 (0.49) | HDAC6HDAC8HDAC1GFERMAPT | |
| SCHEMBL1367688 | 0.87 | HDAC6 (0.49) | HDAC6HDAC8HDAC1GFERMAPT | |
| SCHEMBL1364785 | 0.87 | HDAC6 (0.49) | HDAC6HDAC8HDAC1GFERMAPT | |
| SCHEMBL16302074 | 0.86 | HDAC6 (0.62) | HDAC6HDAC8HDAC1GFERMAPT | |
| SCHEMBL16302085 | 0.85 | HDAC1 (0.51) | HDAC6HDAC8HDAC1MAPTLMNA | |
| SCHEMBL12460163 | 0.85 | HDAC1 (0.51) | HDAC6HDAC8HDAC1MAPTLMNA | |
| SCHEMBL16581065 | 0.84 | HDAC6 (0.47) | HDAC6HDAC8HDAC1GFERSMN1; SMN2 | |
| SCHEMBL16302069 | 0.84 | HDAC6 (0.47) | HDAC6HDAC8HDAC1GFERSMN1; SMN2 | |
| SCHEMBL12428589 | 0.80 | TDP1 (0.50) | LMNASMN1; SMN2NPC1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399452-B2 | Anticancer agents; antiproliferative agenst; antiprotozoa agents | METHYLGENE INC. (CA) | 2013-03-19 | — | — | US | disclosed |
| EP-2489657-A2 | Inhibitors of histone deacetylase | MethylGene Inc. (CA) | 2012-08-22 | — | — | EP | disclosed |
| EP-2343286-A1 | Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2011-07-13 | — | — | EP | disclosed |
| WO-2009137503-A1 | HDAC INHIBITORS AND USES THEREOF | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009137462-A2 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2008055068-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-05-08 | — | — | WO | disclosed |