Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.32 |
| ▸ | HCN1 | O60741 | 1/20 | 0.31 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7966667 | 0.99 | MAP3K7 (0.34) | MAP3K7BRD4PARP1HTR3AHTR4 | |
| SCHEMBL7975460 | 0.94 | MAP3K7 (0.34) | MAP3K7IRAK4HCN1HCN4ADRA1D | |
| SCHEMBL7478323 | 0.93 | MAP3K7 (0.31) | MAP3K7BRD4HCN1HCN4ADRA1D | |
| Hydrochloric Acid SCHEMBL7469087 | 0.92 | MAP3K7 (0.34) | MAP3K7HTR3AHTR4IRAK4HCN1 | |
| SCHEMBL7964805 | 0.92 | MAP3K7 (0.33) | MAP3K7IRAK4HCN1HCN4ADRA1D | |
| SCHEMBL7978134 | 0.92 | MAP3K7 (0.33) | MAP3K7PARP1IRAK4HCN1HCN4 | |
| Hydrochloric Acid SCHEMBL7965773 | 0.91 | MAP3K7 (0.33) | MAP3K7IRAK4HCN1HCN4ADRA1D | |
| SCHEMBL7480306 | 0.91 | MAP3K7 (0.33) | MAP3K7IRAK4HCN1HCN4ADRA1D | |
| Hydrochloric Acid SCHEMBL7971987 | 0.90 | MAP3K7 (0.39) | MAP3K7BRD4 | |
| Hydrochloric Acid SCHEMBL7954938 | 0.90 | MAP3K7 (0.33) | MAP3K7BRD4PARP1IRAK4HCN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |