Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598394 | 0.85 | HSP90AA1 (0.30) | HSP90AA1HSP90AB1 | |
| SCHEMBL931647 | 0.80 | NPC1 (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL929610 | 0.79 | TRIM24 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148450 | 0.76 | HSP90AA1 (0.32) | HSP90AA1HSP90AB1 | |
| SCHEMBL3702596 | 0.75 | HSP90AA1 (0.31) | HSP90AA1HSP90AB1 | |
| SCHEMBL13983495 | 0.75 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL930067 | 0.75 | CRBN (0.37) | — | |
| SCHEMBL16772875 | 0.75 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1 | |
| SCHEMBL421415 | 0.74 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL419879 | 0.73 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616063-A1 | HSP90 INHIBITORS FOR TREATING NON-SMALL CELL LUNG CANCERS IN WILD-TYPE EGFR AND/OR KRAS PATIENTS | Synta Pharmaceuticals Corp. (US) | 2013-07-24 | — | — | EP | claimed |
| EP-2575810-A1 | CANCER THERAPY USING A COMBINATION OF A HSP90 INHIBITORY COMPOUND AND A TOPOISOMERASE II INHIBITOR | Synta Pharmaceuticals Corp. (US) | 2013-04-10 | — | — | EP | claimed |
| WO-2012037072-A1 | HSP90 INHIBITORS FOR TREATING NON-SMALL CELL LUNG CANCERS IN WILD-TYPE EGFR AND/OR KRAS PATIENTS | SYNTA PHARMACEUTICALS CORPORATION (US) | 2012-03-22 | — | — | WO | claimed |
| WO-2011149824-A1 | CANCER THERAPY USING A COMBINATION OF A HSP90 INHIBITORY COMPOUND AND A TOPOISOMERASE II INHIBITOR | SYNTA PHARMACEUTICALS CORP. (US) | 2011-12-01 | — | — | WO | claimed |