Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960372 | 1.00 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7963094 | 1.00 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960506 | 0.96 | PDE4A (0.66) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960371 | 0.94 | PDE4A (0.60) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7963725 | 0.92 | PDE4A (0.64) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7961898 | 0.92 | PDE4A (0.64) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960386 | 0.91 | PDE4A (0.63) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951793 | 0.91 | PDE4A (0.62) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7951778 | 0.90 | PDE4A (0.61) | PDE4AKCNH2PDE4BPDE4CPDE4D | |
| SCHEMBL7960496 | 0.90 | PDE4A (0.61) | PDE4AKCNH2PDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |