Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.55 |
| ▸ | MTOR | P42345 | 6/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.44 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1578581 | 0.89 | CSNK1D (0.49) | PIK3CAMTORPIK3R1CSNK1DCSNK1E | |
| SCHEMBL12652784 | 0.85 | PIK3CA (0.47) | PIK3CAMTORPIK3R1CSNK1DCSNK1E | |
| SCHEMBL7955273 | 0.85 | PIK3CA (0.49) | PIK3CAMTORPIK3R1PIK3CBPIK3CG | |
| SCHEMBL8059503 | 0.84 | PIK3CA (0.64) | PIK3CAMTORPIK3R1CSNK1DCSNK1E | |
| SCHEMBL7952852 | 0.84 | PIK3CA (0.46) | PIK3CAMTORPIK3R1CSNK1DCSNK1E | |
| SCHEMBL7952901 | 0.83 | PIK3CA (0.47) | PIK3CAMTORPIK3R1PIK3CBPIK3CG | |
| SCHEMBL7953012 | 0.83 | PIK3CA (0.52) | PIK3CAMTORPIK3R1PIK3CBPIK3CG | |
| SCHEMBL12618364 | 0.82 | PIK3CA (0.44) | PIK3CAMTORPIK3R1CSNK1DCSNK1E | |
| SCHEMBL7953231 | 0.81 | PIK3CA (0.51) | PIK3CAMTORPIK3R1PIK3CBPIK3CG | |
| SCHEMBL25618869 | 0.79 | PIK3CA (0.48) | PIK3CAMTORCSNK1DCSNK1EPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD. (SG) | 2011-05-05 | — | — | US | disclosed |
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD. (SG) | 2011-05-05 | — | — | US | disclosed |
| WO-2009157880-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD (SG) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | MTOR, PIK3CA, TYMP | PIK3CA 2/4885MTOR 1/4885PIK3R1 92/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.