SCHEMBL7954973

SCHEMBL7954973

CC(C)(Cl)[C](Cl)Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1504537 0.80
SCHEMBL7041977 0.74
SCHEMBL28172498 0.73
SCHEMBL10778589 0.73
SCHEMBL94994 0.73
Chloromethane SCHEMBL10458728 0.71
SCHEMBL8568543 0.70 TSHR (0.36)
Tetrachloroethylene SCHEMBL7060988 0.70 TSHR (0.60)
SCHEMBL11161906 0.70
SCHEMBL4727 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10882861-B2 Purine nucleotide derivatives THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2021-01-05 US claimed
US-20190300532-A1 PURINE NUCLEOTIDE DERIVATIVES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2019-10-03 US claimed
WO-2017201382-A1 PURINE NUCLEOTIDE DERIVATIVES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2017-11-23 WO claimed
US-4672110-A WITH TRIALKYLPHOSPHINE OR TRIALKYLPHOSPHORAMIDE NORTHWESTERN UNIVERSITY (US) 1987-06-09 US claimed
US-10882861-B2 Purine nucleotide derivatives THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2021-01-05 US disclosed
US-20190300532-A1 PURINE NUCLEOTIDE DERIVATIVES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2019-10-03 US disclosed
US-9976000-B2 Aqueous gel NATIONAL UNIVERSITY CORP. HOKKAIDO UNIVERSITY (JP) 2018-05-22 US disclosed
WO-2017201382-A1 PURINE NUCLEOTIDE DERIVATIVES THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2017-11-23 WO disclosed
US-20150133566-A1 AQUEOUS GEL OSAKA ORGANIC CHEMICAL INDUSTRY LTD. (JP) 2015-05-14 US disclosed
US-6197944-B1 OLIGODEOXYNUCLEOTIDES INTEGRATED DNA TECHNOLOGIES, INC. 2001-03-06 US disclosed
US-5962425-A HYDRIDIZING OLIGONUCLEOTIDE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1999-10-05 US disclosed
US-5644048-A Process for preparing phosphorothioate oligonucleotides ISIS PHARMACEUTICALS, INC. (US) 1997-07-01 US disclosed
WO-1994019363-A1 PROCESS FOR PREPARING PHOSPHOROTHIOATE OLIGONUCLEOTIDES ISIS PHARMACEUTICALS, INC. (US) 1994-09-01 WO disclosed
US-5210264-A S-(2,4-dichlorobenzyl)-β-cyanoethyl phosphorothioate diester ISIS PHARMACEUTICALS, INC. (US) 1993-05-11 US disclosed
US-4929607-A ANTITUMOR AGENTS ASTA PHARMA AKTIENGESELLSHAFT 1990-05-29 US disclosed
WO-1989005358-A1 DNA AND RNA MOLECULES STABILIZED BY MODIFICATIONS OF THE 3'-TERMINAL PHOSPHODIESTER LINKAGE AND THEIR USE AS NUCLEIC ACID PROBES AND AS THERAPEUTIC AGENTS TO BLOCK THE EXPRESSION OF SPECIFICALLY TARGETED GENES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1989-06-15 WO disclosed
US-4786724-A INTERMEDIATES FOR SOLID PHASE SYNTHESIS NORTHWESTERN UNIVERSITY (US) 1988-11-22 US disclosed
US-4786724-A INTERMEDIATES FOR SOLID PHASE SYNTHESIS NORTHWESTERN UNIVERSITY (US) 1988-11-22 US disclosed
US-4672110-A WITH TRIALKYLPHOSPHINE OR TRIALKYLPHOSPHORAMIDE NORTHWESTERN UNIVERSITY (US) 1987-06-09 US disclosed
US-4153696-A RENAL CIRCULATION PROMOTERS DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) 1979-05-08 US disclosed