Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.52 |
| ▸ | MTOR | P42345 | 6/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | SCTR | P47872 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953276 | 0.98 | PIK3CA (0.52) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL7954509 | 0.90 | PIK3CA (0.50) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL7955273 | 0.89 | PIK3CA (0.49) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL7954721 | 0.88 | PIK3CA (0.48) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL7953231 | 0.86 | PIK3CA (0.51) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL7952901 | 0.85 | PIK3CA (0.47) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL6898715 | 0.85 | MTOR (0.67) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL12910338 | 0.85 | FLT3 (0.55) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL7956746 | 0.84 | PIK3CA (0.47) | FLT3PIK3CAMTORPIK3R1PIK3CB | |
| SCHEMBL8062689 | 0.84 | PIK3CA (0.64) | FLT3PIK3CAMTORPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD. (SG) | 2011-05-05 | — | — | US | disclosed |
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD. (SG) | 2011-05-05 | — | — | US | disclosed |
| WO-2009157880-A1 | PYRAZINE SUBSTITUTED PURINES | S*BIO PTE LTD (SG) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105500-A1 | PYRAZINE SUBSTITUTED PURINES | MTOR, PIK3CA, TYMP | FLT3 551/4885PIK3CA 2/4885MTOR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.