SCHEMBL7955909

SCHEMBL7955909

[c]1cc(-c2ccncc2)cc(-c2cccnc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 5/20 0.56
CYP3A4 P08684 3/20 0.56
ALDH1A1 P00352 2/20 0.56
CYP1A2 P05177 1/20 0.56
CYP11B2 P19099 2/20 0.49
DYRK1A Q13627 1/20 0.49
DYRK1B Q9Y463 1/20 0.49
MKNK1 Q9BUB5 4/20 0.46
MKNK2 Q9HBH9 4/20 0.46
CYP2C9 P11712 2/20 0.46
CYP2B6 P20813 2/20 0.46
CYP2C19 P33261 1/20 0.46
MEN1 O00255 1/20 0.46
PSIP1 O75475 1/20 0.46
AXL P30530 1/20 0.46
PIK3CA P42336 1/20 0.45
NOTUM Q6P988 1/20 0.45
CYP19A1 P11511 3/20 0.44
KIF11 P52732 1/20 0.44
CYP17A1 P05093 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7953768 0.92 CYP2A6 (0.65) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2
SCHEMBL9957709 0.91 CYP2A6 (0.58) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2
SCHEMBL12068188 0.86 CYP2A6 (0.68) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2
SCHEMBL12070033 0.86 CYP2A6 (0.68) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2
SCHEMBL19817613 0.84 CYP2A6 (0.65) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2
SCHEMBL9958311 0.84 NOTUM (0.65) MKNK1PIK3CANOTUMKIF11KDM4E
SCHEMBL29626674 0.84 CYP2A6 (0.79) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2
SCHEMBL5924678 0.84 MAPT (0.58) DYRK1ANOTUMKIF11LMNATP53
SCHEMBL320526 0.84 CYP2A6 (0.79) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2
SCHEMBL24492814 0.82 CYP2A6 (0.62) CYP2A6CYP3A4ALDH1A1CYP1A2CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1151147-C Indole derivatives as 5 -HT receptor antagonist ʷ��˿�������ȳ�ķ���޹�˾ 2004-05-26 CN disclosed
US-6235758-B1 CENTRAL NERVOUS SYSTEM DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2001-05-22 US disclosed
EP-0808312-B1 INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP disclosed
US-5990133-A TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY OR DEPRESSION SMITHKLINE BEECHAM P.L.C. (GB) 1999-11-23 US disclosed
CN-1179156-A Indole derivatives as 5-HT receptor antagonists SMITHKINE BEECHAM PLC (GB) 1998-04-15 CN disclosed