Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 6/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314254 | 0.82 | NPC1 (0.77) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL30886966 | 0.82 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL20791625 | 0.82 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL29210745 | 0.82 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL19617551 | 0.82 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9AAPP | |
| Hydrochloric Acid SCHEMBL20135246 | 0.81 | MEN1 (0.62) | MEN1KMT2ANPC1RAB9AAPP | |
| SCHEMBL29264373 | 0.79 | MEN1 (0.59) | MEN1KMT2ANPC1RAB9AILK | |
| SCHEMBL2710382 | 0.78 | KMT2A (1.00) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL7968273 | 0.77 | KMT2A (0.57) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL29858428 | 0.77 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |