Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 6/20 | 0.43 |
| ▸ | AGXT | P21549 | 2/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823686 | 1.00 | TAAR1 (0.56) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL264969 | 0.82 | SLC6A2 (0.63) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL4070796 | 0.82 | TAAR1 (0.52) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL3442085 | 0.80 | TAAR1 (0.56) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL2136637 | 0.79 | SLC6A4 (0.52) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL18704005 | 0.79 | SLC6A4 (0.52) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL9511773 | 0.77 | SLC6A2 (0.47) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL16234919 | 0.77 | TAAR1 (0.47) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL3442133 | 0.77 | TAAR1 (0.47) | TAAR1SLC6A4SLC6A2SLC6A3MAOB | |
| SCHEMBL436099 | 0.76 | AOC3 (0.52) | TAAR1SLC6A4SLC6A2SLC6A3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274715-B1 | SEMISYNTHETIC MACROLIDES, USEFUL IN BACTERIAL INFECTIONS TREATMENT AND PREVENTION, HAS LESS POTENTIAL FOR DEVELOPING RESISTANCE, IMPROVED OR MODIFIED PROFILES OF DESIRED GRAM-NEGATIVE ACTIVITY | ABBOTT LABORATORIES | 2001-08-14 | — | — | US | disclosed |