Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | SMO | Q99835 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | OGA | O60502 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10563838 | 0.84 | MAPT (0.70) | MAPTSMN1; SMN2KDM4ECYP2C9CYP2C19 | |
| SCHEMBL2527454 | 0.81 | MAPT (0.59) | MAPTSMN1; SMN2SMOKDM4ECYP3A4 | |
| SCHEMBL23207522 | 0.80 | KDM4E (0.62) | MAPTSMN1; SMN2KDM4ECYP3A4CYP2C9 | |
| SCHEMBL6793180 | 0.80 | MAPT (0.65) | MAPTSMN1; SMN2KDM4ECYP2C9CYP2C19 | |
| SCHEMBL29959269 | 0.80 | MAPT (0.62) | MAPTSMN1; SMN2KDM4ECYP3A4CYP2C9 | |
| SCHEMBL8082196 | 0.80 | SMN1; SMN2 (0.62) | MAPTSMN1; SMN2SMOKDM4ECYP2C9 | |
| SCHEMBL23839530 | 0.79 | MAPT (0.57) | MAPTSMN1; SMN2SMOKDM4ECYP2C9 | |
| SCHEMBL23839528 | 0.79 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2SMOKDM4ECYP3A4 | |
| SCHEMBL2734322 | 0.79 | SMN1; SMN2 (0.79) | MAPTSMN1; SMN2KDM4ECYP2C9CYP2C19 | |
| SCHEMBL30582921 | 0.79 | KDM4E (0.60) | MAPTSMN1; SMN2KDM4ECYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313127-B1 | FOR THERAPY OF HYPERCHOLESTEROLEMIA OR ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2001-11-06 | — | — | US | disclosed |
| EP-0880501-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028128-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICAL AGENTS | ZENECA LIMITED (GB) | 1997-08-07 | — | — | WO | disclosed |