Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241234 | 1.00 | PIM1 (0.48) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| SCHEMBL7241236 | 1.00 | PIM1 (0.48) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| Hydrochloric Acid SCHEMBL7956943 | 0.99 | PIM1 (0.47) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| Hydrochloric Acid SCHEMBL7953424 | 0.99 | PIM1 (0.47) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| SCHEMBL27504553 | 0.86 | MAP2K1 (0.42) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| SCHEMBL14578267 | 0.86 | EED (0.42) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| SCHEMBL14578094 | 0.84 | MAP2K1 (0.41) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| Hydrochloric Acid SCHEMBL7953506 | 0.84 | MAP2K1 (0.41) | PIM1PIM2MAP2K1KDM1ASCN9A | |
| SCHEMBL27504233 | 0.82 | EED (0.47) | PIM1PIM2MAP2K1KDM1AEED | |
| SCHEMBL27487413 | 0.82 | EED (0.47) | PIM1PIM2MAP2K1KDM1AEED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262078-B1 | Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain | SYNTEX (U.S.A.) LLC | 2001-07-17 | — | — | US | disclosed |
| US-6110937-A | A SODIUM CHANNEL BLOCKER TREATING AS LOCAL ANESTHETICS AND IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | SYNTEX USA, INC. (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0869119-A1 | Phenoxymethyl piperidine derivatives being sodium channle blockers | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-07 | — | — | EP | disclosed |
| CN-1194977-A | Phenoxymethyl piperidine derivatives | HOFFMANN LA ROCHE (CH) | 1998-10-07 | — | — | CN | disclosed |