Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960769 | 0.96 | NPY1R (0.53) | NPY1RKDM4ECYP1A2OPRK1EGFR | |
| Hydrochloric Acid SCHEMBL7957055 | 0.94 | NPY1R (0.55) | NPY1RKDM4EOPRK1EGFRSRC | |
| SCHEMBL7963325 | 0.89 | NPY1R (0.54) | NPY1RKDM4EOPRK1MEN1KMT2A | |
| SCHEMBL7957061 | 0.85 | NPY1R (0.54) | NPY1RKDM4ECYP1A2EGFRSRC | |
| SCHEMBL8801207 | 0.85 | NPY1R (0.56) | NPY1R | |
| SCHEMBL7949157 | 0.85 | NPY1R (0.56) | NPY1RKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7959155 | 0.85 | NPY1R (0.50) | NPY1ROPRK1MAPTSMN1; SMN2 | |
| SCHEMBL7959706 | 0.84 | NPY1R (0.55) | NPY1RKDM4ECYP1A2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL7948522 | 0.84 | NPY1R (0.55) | NPY1RMAPTALDH1A1HSD17B10 | |
| SCHEMBL7959480 | 0.84 | NPY1R (0.51) | NPY1RMEN1KMT2AATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |
| EP-0789688-A4 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0789688-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997009308-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |