Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948041 | 0.96 | PDE5A (0.77) | PDE5APDE4BLMNA | |
| SCHEMBL7955540 | 0.88 | PDE5A (0.73) | PDE5APDE4B | |
| SCHEMBL7947681 | 0.88 | PDE5A (0.88) | PDE5APDE4B | |
| SCHEMBL7955490 | 0.88 | PDE5A (0.90) | PDE5APDE4B | |
| SCHEMBL7961483 | 0.87 | PDE5A (0.81) | PDE5APDE4B | |
| SCHEMBL7961785 | 0.86 | PDE5A (0.94) | PDE5APDE4B | |
| SCHEMBL7959070 | 0.86 | PDE5A (0.98) | PDE5APDE4B | |
| SCHEMBL7947735 | 0.86 | PDE5A (0.79) | PDE5APDE4B | |
| SCHEMBL7956827 | 0.86 | PDE5A (0.87) | PDE5APDE4B | |
| SCHEMBL7962059 | 0.85 | PDE5A (1.00) | PDE5APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | claimed |
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |