Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.70 |
| ▸ | HTR2C | P28335 | 8/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.70 |
| ▸ | DRD2 | P14416 | 5/20 | 0.70 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7948566 | 0.91 | HTR2A (0.72) | HTR2AHTR2CKCNH2DRD2TLR9 | |
| SCHEMBL7952289 | 0.91 | HTR2A (0.68) | HTR2AHTR2CKCNH2DRD2TLR9 | |
| SCHEMBL7958025 | 0.89 | HTR2A (0.72) | HTR2AHTR2CKCNH2DRD2TLR9 | |
| SCHEMBL7959325 | 0.83 | HTR2A (0.75) | HTR2AHTR2CKCNH2DRD2TLR9 | |
| SCHEMBL7948313 | 0.83 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7948318 | 0.83 | HTR2A (0.85) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL7956022 | 0.82 | HTR2A (0.80) | HTR2AHTR2CKCNH2DRD2TLR9 | |
| SCHEMBL7959592 | 0.81 | HTR2A (0.62) | HTR2AHTR2CKCNH2DRD2TLR9 | |
| SCHEMBL7958814 | 0.80 | HTR2A (0.80) | HTR2AHTR2CKCNH2DRD2TLR9 | |
| SCHEMBL7958133 | 0.79 | HTR2A (0.87) | HTR2AHTR2CKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316468-B1 | Phenylindole derivatives as 5-HT2A receptor antagonists | MERCK SHARP & DOHME LTD. | 2001-11-13 | — | — | US | claimed |
| WO-1999011641-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | claimed |
| US-6316468-B1 | Phenylindole derivatives as 5-HT2A receptor antagonists | MERCK SHARP & DOHME LTD. | 2001-11-13 | — | — | US | disclosed |
| WO-1999011641-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | disclosed |