Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 13/20 | 0.62 |
| ▸ | MAOA | P21397 | 7/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543542 | 1.00 | MAOB (0.62) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL8542594 | 0.98 | MAOB (0.64) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL7024761 | 0.93 | MAOB (0.66) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL11802724 | 0.92 | MAOB (0.72) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL7405667 | 0.88 | MAOB (0.68) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL108114 | 0.86 | MAOB (0.74) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL107322 | 0.84 | MAOB (0.83) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL11796757 | 0.84 | MAOB (0.62) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL14382267 | 0.84 | MAOB (0.62) | MAOBMAOAMAPK1TSHRMEN1 | |
| SCHEMBL11798933 | 0.84 | MAOB (0.65) | MAOBMAOAMAPK1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303641-B1 | FOR THERAPY AND PROPHYLAXIS OF DISEASES CHARACTERIZED BY ABNORMAL CELL DIFFERENTIATION AND/OR CELL PROLIFERATION SUCH AS PSORIASIS AND CANCER | LEO PHARMACEUTICALS PRODUCTS LTD. (DK) | 2001-10-16 | — | — | US | disclosed |
| EP-0984940-A1 | CYANOAMIDINES AS CELL PROLIFERATION INHIBITORS | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054147-A1 | CYANOAMIDINES AS CELL PROLIFERATION INHIBITORS | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 1998-12-03 | — | — | WO | disclosed |
| US-5696140-A | FOR TREATMENT OF ASTHMA, ALLERGIES, NERVOUS SYSTEM DISORDERS OR CANCER | LEO PHARMACEUTICAL PRODUCTS LTD. (DK) | 1997-12-09 | — | — | US | disclosed |