Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | ESR1 | P03372 | 1/20 | 0.72 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413078 | 0.88 | MAPT (0.71) | POLBHPGDKMT2AMAPTESR1 | |
| SCHEMBL7418609 | 0.88 | MAPT (0.71) | POLBHPGDKMT2AMAPTESR1 | |
| SCHEMBL7957481 | 0.88 | — | — | |
| SCHEMBL7961315 | 0.85 | MAPT (0.67) | POLBHPGDKMT2AMAPTESR1 | |
| SCHEMBL7960878 | 0.85 | KDM4E (0.87) | POLBHPGDKMT2AMAPTKDM4E | |
| SCHEMBL7949782 | 0.84 | POLB (0.73) | POLBHPGDKMT2AMAPTKDM4E | |
| SCHEMBL7420472 | 0.84 | ESR1 (0.66) | MAPTESR1PTK2BTDP1 | |
| SCHEMBL7964123 | 0.84 | ESR1 (0.66) | MAPTESR1PTK2BTDP1 | |
| SCHEMBL7964315 | 0.83 | POLB (0.71) | POLBHPGDKMT2AMAPTKDM4E | |
| SCHEMBL7959850 | 0.83 | POLB (0.85) | POLBHPGDKMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639760-A | USEFUL AS MUSCLE RELAXANTS, SEDATIVES, ANXIOLYTICS, ANTICONVULSANTS, AND ANTIDOTES FOR DRUG OVERDOSE | MARYANOFF BRUCE E (US) | 1997-06-17 | — | — | US | claimed |
| US-6218384-B1 | FOR THERAPY OF ANXIETY, MUSCLE SPASMS, SLEEPLESSNESS, CONVULSIONS AND BENZODIAZEPINE OVERDOSES | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-04-17 | — | — | US | disclosed |
| US-5639760-A | USEFUL AS MUSCLE RELAXANTS, SEDATIVES, ANXIOLYTICS, ANTICONVULSANTS, AND ANTIDOTES FOR DRUG OVERDOSE | MARYANOFF BRUCE E (US) | 1997-06-17 | — | — | US | disclosed |