Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 20/20 | 0.67 |
| ▸ | PRKD2 | Q9BZL6 | 14/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.67 |
| ▸ | PRKCA | P17252 | 1/20 | 0.57 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1592068 | 0.91 | PRKD1 (0.71) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL1592677 | 0.88 | PRKD1 (0.72) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL1578866 | 0.87 | PRKD1 (0.71) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL7959994 | 0.87 | PRKD1 (0.71) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL1579274 | 0.85 | PRKD1 (0.75) | PRKD1PRKD2ADRB1 | |
| SCHEMBL1578884 | 0.85 | PRKD1 (0.76) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL7957965 | 0.84 | PRKD1 (0.74) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL1579167 | 0.83 | PRKD1 (0.76) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL1578895 | 0.82 | PRKD1 (0.74) | PRKD1PRKD2ADRB1PRKCAPRKCD | |
| SCHEMBL1578818 | 0.81 | PRKD1 (1.00) | PRKD1PRKD2ADRB1PRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150230-A1 | 2,4'-BIPYRIDINYL COMPOUNDS AS PROTEIN KINASE D INHIBITORS USEFUL FOR THE TREATMENT OF IA HEART FAILURE AND CANCER | NOVARTIS AG (CH) | 2009-12-17 | — | — | WO | disclosed |