Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.47 |
| ▸ | HTR6 | P50406 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960156 | 1.00 | PDE4A (0.56) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7960332 | 1.00 | PDE4A (0.56) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7951799 | 0.95 | PDE4A (0.57) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7960245 | 0.94 | PDE4A (0.58) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7960298 | 0.93 | KCNH2 (0.47) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7953511 | 0.93 | KCNH2 (0.47) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7954854 | 0.93 | KCNH2 (0.47) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7960385 | 0.90 | PDE4A (0.57) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7960389 | 0.90 | PDE4A (0.57) | PDE4AKCNH2PDE4BPDE4DPDE4C | |
| SCHEMBL7951741 | 0.89 | PDE4A (0.54) | PDE4AKCNH2PDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331548-B1 | PREVENTION OR TREATMENT OF CYTOKINE RELATED DISEASES | SUNTORY LIMITED (JP) | 2001-12-18 | — | — | US | disclosed |
| EP-0978516-A1 | 1-CYCLOALKYL-1,8-NAPHTHYRIDIN-4-ONE DERIVATIVES WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SUNTORY LIMITED (JP) | 2000-02-09 | — | — | EP | disclosed |