Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 2/20 | 0.60 |
| ▸ | F10 | P00742 | 2/20 | 0.60 |
| ▸ | F11 | P03951 | 2/20 | 0.60 |
| ▸ | F7 | P08709 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GAPDH | P04406 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974859 | 0.82 | F9 (0.68) | F9F10F11F7KDM4E | |
| SCHEMBL10140103 | 0.82 | F9 (0.39) | F9F10F11F7KDM4E | |
| SCHEMBL16258970 | 0.81 | F9 (0.48) | F9F10F11F7KDM4E | |
| SCHEMBL7975674 | 0.80 | F9 (0.56) | F9F10F11F7KDM4E | |
| SCHEMBL7978374 | 0.76 | F9 (0.54) | F9F10F11F7ALDH1A1 | |
| SCHEMBL20307797 | 0.76 | F9 (0.47) | F9F10F11F7KDM4E | |
| SCHEMBL10172525 | 0.76 | F10 (0.59) | F9F10F11F7KDM4E | |
| SCHEMBL7973776 | 0.75 | F10 (1.00) | F9F10F11F7PLAU | |
| SCHEMBL7978364 | 0.74 | F10 (0.60) | F9F10F11F7KDM4E | |
| SCHEMBL7978212 | 0.73 | F9 (0.65) | F9F10F11F7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-A1 | Heterocyclic compounds as factor IXA inhibitors. | Merck Sharp & Dohme Corp. (US) | 2014-11-26 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |