Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.84 |
| ▸ | JAK1 | P23458 | 16/20 | 0.82 |
| ▸ | JAK3 | P52333 | 4/20 | 0.79 |
| ▸ | TYK2 | P29597 | 3/20 | 0.79 |
| ▸ | STK10 | O94804 | 1/20 | 0.78 |
| ▸ | ABL1 | P00519 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | CSF1R | P07333 | 1/20 | 0.78 |
| ▸ | FLT1 | P17948 | 1/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | FLT4 | P35916 | 1/20 | 0.78 |
| ▸ | FLT3 | P36888 | 1/20 | 0.78 |
| ▸ | STAT1 | P42224 | 1/20 | 0.78 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.78 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | MERTK | Q12866 | 1/20 | 0.78 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.78 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.78 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2237580 | 0.91 | JAK2 (1.00) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL218626 | 0.90 | JAK2 (1.00) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL2237245 | 0.90 | JAK2 (1.00) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL2237575 | 0.90 | JAK1 (1.00) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL2239378 | 0.89 | JAK2 (0.85) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL2237614 | 0.89 | JAK1 (1.00) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL7966699 | 0.89 | JAK1 (0.84) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL218472 | 0.89 | JAK1 (1.00) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL18405534 | 0.89 | JAK2 (0.84) | JAK2JAK1JAK3TYK2STK10 | |
| SCHEMBL217727 | 0.89 | JAK2 (1.00) | JAK2JAK1JAK3TYK2STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022068933-A1 | COMPOUNDS AND METHODS OF TREATING DISEASES | CULLGEN (SHANGHAI) , INC. (CN) | 2022-04-07 | — | — | WO | disclosed |
| WO-2020200291-A1 | COMPOUNDS AND METHODS OF TREATING CANCERS | CULLGEN (SHANGHAI) , INC. (CN) | 2020-10-08 | — | — | WO | disclosed |
| WO-2010010190-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |