Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.67 |
| ▸ | GSR | P00390 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.60 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7877725 | 0.96 | ADORA2A (0.72) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL7869239 | 0.93 | GSR (0.69) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL7875800 | 0.92 | GSR (0.72) | ADORA2AGSRKMT2ATDP1MEN1 | |
| SCHEMBL7874381 | 0.92 | ADORA2A (0.78) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL7967139 | 0.91 | ADORA2A (0.66) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL7878018 | 0.91 | ADORA2A (0.52) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL30227435 | 0.89 | ADORA2A (0.63) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL30227214 | 0.89 | ADORA2A (0.53) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL7877818 | 0.89 | ADORA2A (0.53) | ADORA2AGSRKMT2ATDP1MEN1 | |
| Trifluoroacetic Acid SCHEMBL7956392 | 0.89 | ADORA2A (0.63) | ADORA2AGSRKMT2ATDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143235-A1 | METHODS AND COMPOSITIONS FOR TREATING CYTOKINE STORM INFECTIONS, INCLUDING COVID-19, BY INHIBITING CCR5/CCL5 INTERACTION | IncellDx, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| WO-2021222069-A1 | METHODS AND COMPOSITIONS FOR TREATING CYTOKINE STORM INFECTIONS, INCLUDING COVID-19, BY INHIBITING CCR5/CCL5 INTERACTION | INCELLDX, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| US-6242459-B1 | Substituted bis-acridines and related compounds as CCR5 receptor ligands, anti-inflammatory agents and anti-viral agents | SMITHKLINE BEECHAM CORPORATION | 2001-06-05 | — | — | US | disclosed |