Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | MAOA | P21397 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | AR | P10275 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25235776 | 0.89 | MAPT (0.55) | MAPTNPSR1MAOBMAOAL3MBTL1 | |
| SCHEMBL30382383 | 0.89 | MAPT (0.55) | MAPTNPSR1MAOBMAOAL3MBTL1 | |
| SCHEMBL2376112 | 0.84 | MAPT (0.74) | MAPTNPSR1MAOBMAOAL3MBTL1 | |
| SCHEMBL7956659 | 0.84 | MAPT (0.74) | MAPTNPSR1MAOBMAOAL3MBTL1 | |
| SCHEMBL1830692 | 0.84 | STAT3 (0.67) | MAPTNPSR1MAOBMAOAL3MBTL1 | |
| SCHEMBL1822452 | 0.84 | STAT3 (0.67) | MAPTNPSR1MAOBMAOAL3MBTL1 | |
| SCHEMBL25223426 | 0.83 | MAOB (0.73) | MAPTNPSR1MAOBMAOASMN1; SMN2 | |
| SCHEMBL30382981 | 0.83 | MAOB (0.73) | MAPTNPSR1MAOBMAOASMN1; SMN2 | |
| SCHEMBL14692628 | 0.81 | NR1H4 (0.79) | MAPTMAOBMAOAL3MBTL1AR | |
| SCHEMBL14692627 | 0.81 | NR1H4 (0.79) | MAPTMAOBMAOAL3MBTL1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324032-B1 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS INC (US) | 2014-10-01 | — | — | EP | disclosed |
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |